blast cell การใช้

• The column of blast cells arising out of each teloblast is known as a bandlet.
• Teloblasts divide asymmetrically to form small blast cells which wrap around the embryo and extend rostrally.
• Finally, the number of segments within the embryo is defined by the number of divisions and blast cells.
• Acute in acute myeloid leukemia means that the amounts of blast cells are increasing at a very high rate.
• High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations.
• These segmental boundaries were discovered by injecting teloblasts with cell lineage tracers after a few blast cells have already been generated.
• CD33 is expressed in most leukemic blast cells but also in normal hematopoietic cells, the intensity diminishing with maturation of stem cells.
• Early divisions within the leech embryo result in teloblast cells, which are stem cells that divide asymmetrically to create bandlets of blast cells.
• The O, P, and M lineages contribute one blast cell per segment, but the contributions from each blast cell spans a segmental boundary.
• The O, P, and M lineages contribute one blast cell per segment, but the contributions from each blast cell spans a segmental boundary.
• The N and Q teloblasts contribute two blast cells per segment, one making up the anterior half of the segment, the second making up the posterior half of the segment.
• During development, the N and Q bandlets, which eventually have 64 blast cells each, slide past the O, P, and M bandlet, which only have 32 cells.
• Many of the immature blast cells in acute myeloid leukemia have a higher loss of function and thus, a higher inability to carry out normal functions than those more developed immature myeloblast cells in chronic myeloid leukemia ( O Donnell et al . 2012 ).
• The hemangioblast theory, which posits that the RBCs and ECs derive from a common progenitor cell, was developed as researchers observed that receptor knockout mice, such as blast cells derived from embryonic stem ( ES ) cells displayed common gene expression of both hematopoietic and endothelial precursors.
• First, the percentage of undifferentiated progenitor cells, blast cells, is always less than 20 %, and there is considerably more dysplasia, defined as cytoplasmic and nuclear morphologic changes in erythroid, granulocytic and megakaryocytic precursors, than what is usually seen in cases of AML . These changes reflect delayed apoptosis or a failure of programmed cell death.